Study on a Seropharmacological Method for an Effective Antifibrotic Formula

Abstract:

The serum was collected from rats fed on Fuzheng Huayu (FZHY) decoction, and FZHY decoction was lyophilized into powder. And both were incubated with hepatic stellate cells (HSC) and hepatocytes. Then cell morphology and functions were observed to study the seropharmacological methods for antifibrotic traditional Chinese herbs. The results showed that the FZHY powder inhibited cell proliferation and viability. The deactivated rat's sera drawn 1h after FZHY-treatment twice had no cytotoxity, promoted hepatocyte proliferation, and inhibited HSC proliferation. Therefore, this seropharmacological method could be applied for antifibrotic herbal formulae.