Abstract:The effect of Yishen Daozhuo oral liquid on renal function and enzyme histochemistry of adenine induced chronic renal failure in rats was observed. Results showed that the contents of blood urea nitrogen (BUN) and creatinine (Cr) in serum were obviously lowered and the activities of SDH, ALP and ATPase in renal tissues were significantly increased in rats following exposure to the liquid. The biological activities of the liquid were found to be higher than that of Verapamil.