Abstract:The extracting processes of Huanglianjiedu decoction were studies by determining the content of berberine with the method of column chromatography purification.By orthogonal design test,the optimum preparation conditions for shaping the pilule were determined as:extract:PEG6000:water:glycerin=1180404,well mingled and kept in pilulemaking device with temperature at(902),then was dropped in a cooler (20±2)℃ through a dropper (internal/external diameter=25/35mm) at a speed of(10±2)drops/min.