Abstract:Cognition-enhancing effect of Liuwei Dihuang decoction(LW)on SAM was observed by using passive avoidance performance,shuttle box and water maze tests in the present paper.It was showed that memory registration and retention ability,spatial memory as well as conditioned avoid response were all greatly declined in SAMP8.However,chronic administration of LW to SAMP8 enhanced the memory registration and retention ability in passive avoidance performance, promoted the spatial memory ability in water maze test and partially improved the leaning behavior in conditioned avoidance performance.The present results suggested that chronic administration of LW significantly ameliorated agerelated decline of learning and memory ability in SAM.
