Preparation of Xiao'er Xiaochuan Gel in Rectal Administered——Selection of Excipients and Osmotic-promoting Regents

Abstract:

The concentration of ephedrine and pseudoephedrine in rabbit's blood were determined by HPLC method after rectal administered with xiao'er xiaochuan gel.The rectal administered was used by the venous intubation on rabbit's rectal mesentery in vivo. The excipients and osmotic-promoting regents were screened by the blood concentration of above markers.The optimized prescription were made up of oleic acid and azone as osmotic-promoter,and eudragit as excipient.