Mechanism of Guizhi Decoction on Dual-directional Thermoregulation——Effect on AC Activity and cAMP Content in Hypothalamus of Febrile and Hypothermia Rats

Abstract:

In febrile rats induced by fresh yeast,Guizhi decoction could cut down body temperature with weakening AC activity and descending cAMP content in hypothalamus.On the other hand,in hypothermia model induced by aminopyrine,Guizhi decoction could go up body temperature with strengthening AC activity and increasing cAMP content in hypothalamus.The results indicate that Guizhi decoction may regulate body temperature in dual-direction by means of effecting AC activity and promoting or inhibiting hypothalamus intracellular metabolism of cAMP,a febrile medium in center.