Abstract:The components in fraction A of Guizhitang which contained five herbal medicines,i.e.ramulus cinnamomi,radix paeoniae alba,rhizoma zingiberis recens and fructus jujubae,were assigned by comparison of corresponding part of each herbs with HPLC-MS method.From the ionic fragments of MS and the retained time of each peaks in HPLC,the main component of fraction A were assigned.