Abstract:The factors effecting the physical property of cataplasm were investigated by means of the homogeneity,layer residue,flexibility and adhesive ability of the plaster as comprehensive consideration,and adhesive force(180°) while exfoliated as the quantitative marker.The main factors,stirring time,refining temperature,and adding order of matrixs were studied by orthogonal design tests.The optimized procedures were stirring for 20~40minute,plaster at 50℃,and after mixing the excipients and filling material,then adding the bonds.