Abstract:The effect of oxygen stress on myocardial mitochondria of rat and the protective effect of Yi-Xin-Kang capsule(H303)-containing serum on oxygen stress-induced injury by incubating myocardial mitochondria with hydroxy free radical generating system (Fe2+/H2O2) for 30 min,were observed.Result shows Fe2+/H2O3 induced obvious injury of mitochondria concentration-dependently.It was also found that mitochondria were significantly occurred with lipid peroxidation and swelled,the ultrastructures of mitochondria were changed and the content of GSH was markedly reduced.H303-containing serum showed significant protective effects on mitochondria injury induced by oxygen stress,and antagonized mitochondria lipid peroxidation and the decrease of endogenous GSH.The ultrastuctures of mitochondria and their swelling degree were also improved.
