Effect of GeGen Decoction on Inflammatory Media in Joint of Adjuvant Arthritis Rats

Abstract:

The aim of this study was to discuss the anti-inflammation mechanism of GeGen Decoction (GGD).The results showed GGD could significantly inhibit the activity of IL-1 β/TNF-α and decrease the level of PGE₂ in the joint of Adjuvant Arthritis rats by giving GGD (8.2g/kg,16.4g/kg,ig) for three days before modeling till 21 days.It indicates GGD can inhibit the activity of cytokines in the inflammatory area and decrease the level of inflammatory media,which may be one of its anti-inflammation mechanisms of GGD.