Abstract:Applying scopolamine and ischemia-reperfustion to establish murine models for Alzheimer's disease(AD) and vascular dementia(VD),respectively,might help explicate the formula mechanism of Danggui Shaoyao San(DSS).In comparison with the normal group,step-through latency taken by mice injured with scopolamine got shortened(P<0.01),step-through and step-down number of errors increased (P<0.05～0.01);Both drugs used to promote blood circulation and nourish the blood (DCS) and drugs used to nourish the spleen and disperse the pathogenic damp (FBZ) in DSS at low dosage,made step-through latency longer (P<0.05),decreased obviously step-through and step-down number of errors (P<0.05～0.01).If DCS and FBZ were in combination with each other,their cooperative melioration would be furthered;Compared with the sham operational group,step-through latency taken by ICR mice injured with ischemia-reperfusion got shortened(P<0.01),step-through number of errors increased (P<0.01),However,it was FBZ other than DCS that could at high dosage elongate step-through latency (P<0.05),decrease obviously step-through number of errors (P<0.01),antagonize selectively the memory impairment of ICR mice induced by ischemia-reperfusion,those discovery maybe indicated that to nourish the spleen and disperse the pathogenic damp played a more important role in the prevention and treatment of senile dementia than to promote blood circulation and nourish the blood.
