Ligustrazini preconditioning protection on myocardial ischemia and reperfussion injury in the conscious rat

Abstract:

Lgustrazini(20mg·kg^-1 and 40mg·kg^-1) was injected to the conscious rat for 5min,then followed by ischemia 30min/reperfussion 120min,the incidence of VT and VF and mean duration of VT plus VF were decreased with a delayed onset of VT plus VF.In addition,the rise of plasma level of LDH,CPK and the infarct size was attenuated.The result indicated that pretreatment of ligustrazini might mimic IP with cardiacprotection on ischmia/reperfussion.