Experimental Study on the Analgesia Mechanism of Paeornia and Glycyrrhiza Dicoction

Abstract:

The analgesia action was investigated in the pain model caused by formalin,and the content of NO,PGE₂ and SOD of serum and spinal cord of mice with pain model caused by glacialaceticacid were also detected to study analgesia mechanism of Paeonia and Glycyrrhiza Decoction(PGD).The results indicate:(1)In Formalin pain experiment,PGD could restrain peripheral nerve twig action,and inhibit subesequent inflammatory reaction to ease pain in Ⅰ and Ⅱ phase reaction;(2)PGD could decrease the content of NO and PGE₂ of serum and spinal cord of the mice and distinctly enhance the activity of SOD.