Abstract:The protective effect of Yangshou Dan(YSD) on central nervous system in rat with AD was studied.Y-electric maze was used to test the ability of learning and memory of rats,and inspect the content of monoamine neurotransmitters by fluorospectrophotometry.The results showed that YSD could significantly improve the learning and memory ability and increase the weight of adrenal,especially,the level of norepinephrine,5-hydroxytryptamine in hippocampus and cerebral cortex.It's suggested that YSD have the protective against the injuring in rat brain through adjusting the level of monoamine neurotransmitters in brain.