Abstract:Effects of compatible application of RHIZOMA CHUANXIONG and RADIX PAEONIAE RUBRA on regulation of lipid metabolism, scavenging of free radicals and protection of vascular endothelium in rat with hyperlipidemia were investigated. It was found that compatible application of RHIZOMA CHUANXIONG and RADIX PAEONIAE RUBRA reduced total cholesterol (TC), triglyceride(TG), low density lipoprotein, which was obtained by single use of RHIZOMA CHUANXIONG and RADIX PAEONIAE RUBRA, respectively.Conceming scavenging of free radicals and protection of vascular endothelium, compatible application of RRHIZOMA CHUANXIONG and RADIX PAEONIAE RUBRA decreased the malondiadehyde (MDA) with increased release of nitric oxide, but single use of RHIZOMA CHUANXIONG and RADIX PAEONIAE RUBRA did not indicate the same actions,which suggested that compatible application of the two drugs can create a synergism.