Abstract:Objective:To observe the effect of stress and gonadectomy on the mice.Methods:The effect of stress and gonadectomy on sleep in mice,survival time under oxygen lack,climbing time on the string and the freedom action was investigated firstly.Results:The stress and gonadectomy could result in sleep impairment,survival time under oxygen lack and time on the string lowering,the freedom action increase.The effect of stress and gonadectomy on mice was stronger than that of just stress or that of just gonadectomy.This study also indicated TCM complex Ⅰ could alleviated the effect of stress and gonadectomy on the mice.Conclusion:The stress and gonadectomy could result in change activity.