Inhibitory Effect of Sorbaria Sorbifolia Extract on DEN-induced Precancerous Hepatic in Rats

Abstract:

Objective:To investigate the inhibitory effect of Sorbaria Sorbifolia extract on diethylnitrosamine (DEN) induced precancerous hepatic in rats.Methods:Sorbaria Sorbifolia was administrated ig. to rats with DEN-induced precarcinogenesis,Then using the immunohistochemical S-P method,the p53 and bcl-2 proteins were detected.The activities of superoxide dismutase(SOD),glutathione peroxidase (GSH-Px),and the concentrations of malondialdehyde(MDA) were investigated by colorimetric method.Results:Sorbaria Sorbifolia significantly decreased the expression of GST-P,and increased the SOD,GSH-Px and decreased MDA level in serum,liver cell homogenate and liver cell mitochondria.Conclusion:Sorbaria Sorbifolia extract has inhibitory effect on DEN-induced precancerous hepatic in rats.