Effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB2、6-Keto-PGF1α in Blood Stasis Syndromes Model Rats

Abstract:

Ojbect:To study the effects of Fufangdanshenfang on Platelet Adhesion,Aggregation and TXB₂、6-Keto-PGF_1α in Blood Stasis Syndromes Model Rats.Methods:The rat blood stasis syndromes model was caused by subcutaneous injection of Adr and ice-bathing.We studied the effects of Fufangdanshenfang on platelet aggregation,adhesion,TXB₂ and 6-Keto-PGF_1α in blood stasis syndromes model rats.Results:The results indicated that compared with normal rats,the platelet aggregation and platelet adhesion were markedly increased.Fufangdancanfang was antagonized the increase of platelet adhesion and ADP-induced platelet aggregation in model rats.Fufangdancanfang markedly increased the level of TXB₂、6-Keto-PGF_1α in plasma and the content of abdominal aorta tissue 6-Keto-PGF_1α in model rats,but had little effect on the proportion of TXB₂/6-Keto-PGF_1α.Conclusion:The results suggested that rat blood stasis syndromes model of Adr was caused successfully,and we inferred that the effects on the platelet aggregation and platelet adhesion might not be connected with the system TXB₂-PGI₂.Fufangdancanfang was antagonized the increase of platelet adhesion and ADP-induced platelet aggregation in model rats.