Abstract:Objective:To observe the effect of ginkgolide,baiclin and linguitrazin on airway allergic inflammation in Guinea pigs with asthma.Methods:Eosinophil cells count in blood and bronchial alveolar lavage fluid(BALF),as well as total cells count in BALF were measured by traditional methods.Eosinophil cation protein (ECP) level in blood and BALF was detected by radioimmunoassay.Results:Treatments with ginkgolide,baicalin and linguitrazin could significantly inhibit blood eosinophil gathering in asthma animals comparing with the untreated animals.Baicalin and linguitrazin also reduced eosinophil and total cells count in BALF,while ginkgolide only could inhibit the total cells count.All components of TCM concerned had no protection effect on asthma attack.No difference was shown on ECP levels among all groups.Conclusion:Ginkgolide,baicalin and linguitrazin could inhibit the AAI of asthma animals by reducing eosinophol gathering in blood and BALF.There was no protection effect found suggested that the compound of such components might be effective in treating and preventing asthma attack.
