Effects of Active Fractions of Danshen or Sanqi on Platelet Adhesion,Aggregation and TXA2,PGI2 in Normal Rats

Abstract:

We studied the effects of salvianolic acid B(Sa1.B)、Rb、Re and Rg fractions of Danshen or Sanqi on platelet aggregation and adhesion,TXA₂ and PGI₂ in normal rats. The results demonstrated that Re fraction (68mg/kg)and Rg fraction (108mg/kg),given orally,could markedly counteract ADP induced platelet aggregation.Rg fraction (108mg/kg) and Sal.B fraction(48mg/kg) could markedly inhibit platelet adhesion.Rb fraction(112mg/kg) have no effects on platelet aggregation and on adhesion.Rg fraction(108mg/kg) and Sal.B fraction (48mg/kg) could markedly decrease the level of TXA₂,but had little effect on 6-Keto-PGF_1α. Moreover, Rg fraction 108mg/kg could decrease the ration of TXB₂/6-Keto-PGF_1α,too. The results suggested that the inhibition effects on platelet aggregation and adhesion of Rg fraction(108mg/kg) and Sal.B fraction(48mg/kg) of Danshen or Sanqi might be closely related to its inhibition effect on the release of TXA₂ in normal rats.