Abstract:Objective:To explore the inhibitory effect of tumor growth and antiangiogenesis of Gubenxiaoliu capsule(GC) on Lewis lung carcinoma of mouse.Methods:In vivo animal experiment was used to investigate the growth of mouse tumor.Immunohistochemically(S-P) and quantitative pathologic image analysis were used to investigate the microvesel dencity(MVD) and expression of vascular endothelial growth factor(VEGF) in tumor tissue.Results:The inhibitory rates on mouse tumor of GC group,Chemotherapy group and GC+Chemotherapy group are 40.58%, 52.69%, 61.09% respectively,The inhibitory rates are significantly higher than the control,MVD and expression of VEGF of GC group and GC+Chemotherapy group and MVD of Chemotherapy group decreased significantly.Conelusion:GC could inhibit the growth and angiogenesis of Lewis lung carcinoma of mouse.
