Abstract:Objective:To observe pharmacological effect of Longbi xintong granule.Method:We observed the analgesia effect of the granule by acid induced wristle and hot-plate induced pain in mice.Its anti-inflmmatory effect was tested in xylene caused mice ear edema,cotton caused granuloma hyperplasia in rat,and carrageenin caused paw edema in rat.Its antimicrobial effect was tested in vitro and vivo in mice.Results:Longbi xintong Granule could significantly reduce the wristle reaction times in mice,prolong the latent time of reaction on hot-plate in mice.It could significantly inhibit the ear edema caused by xylene in mice,granuloma hyperplasia caused by cotton and edema of paws caused by carrageenin in rats.Longbi xintong Granule could significantly reduce the content of PGE2 in paw tissue and serum,and could significantly reduce the content of MDA in paw tissue in inflammatory rats.It could inhibit capillary permeability and improve the antimicrobial activity in vivo and vitro.Conclusion:Longbi xintong Granule has obvious effect on analgesia,anti-inflmmation and antibiosis.
