Optimization of Extraction Technology for Lovastatin from Monascus purpureus by Orthogonal Test

Abstract:

Objective:To optimize extraction technology of lovastatin from Monascus purpureus. Method: With composite score of yield of dry extract and transfer rate of lovastatin as index,taking extraction times, extraction time, the concentration and amount of ethanol as factors, extraction technology of lovastatin from M. purpureus was optimized by L₉ (3⁴) orthogonal test. Result: Optimum extraction technology was as follows:reflux extracted 2 times with 6 times the amount of 95% ethanol,0.5 h per time. Conclusion: This optimized extraction technology was feasible, stable and reasonable with high yield of lovastatin.