Abstract:Objective:To investigate effect of gel material ratio on in vitro percutaneous absorption of basil oil transdermal gel. Method: With CMC-Na and PVA as accessories to prepared basil oil transdermal gel.Modified Franz diffusion cell was used,percutaneous penetration test was isolated with mouse dorsal skin as barrier,with the content eugenol as index,percutaneous permeation quantity of basil oil was detected by gas chromatography. Result: Ratio of polyvinyl alcohol and sodium carboxymethyl cellulose showed no significant effect on transdermal ability of basil oil,test determined 2∶4 was the best ratio;But their concentration in gel matrix had a certain influence on transdermal ability of basil oil,the content of them with 25% was optimal. Conclusion: These results suggested that basil oil transdermal gel could greatly improve efficacy of basil oil.
