Abstract:Objective:To study the protective effects of acanthoic acid (AA) against acute liver injury. Method: Sixty mice were andomly divided into six groups: the normal group, the ethanol model group, silymarin group (100 mg·kg-1), high-dose AA group (30 mg·kg-1),middle-dose AA group (10 mg·kg-1) and low-dose AA group (5 mg·kg-1). Each group received medicine by gavage every 12 hrs for a total of 3 doses.Except for normal group, the other mice were received 60% ethanol (5 g·kg-1) 1 h. After administrayion. The thehepatic pathological and biochemical index changes in rats were observed. Result: The high-dose AA group and the middle-dose AA group can reduce the level of ALT(25±6),(31±8) U·L-1, AST(157±23),(187±18) U·L-1,TNF-α(32±4.62),(41±5.3) μg·L-1 and TG(190±23),(257±23) mmol·L-1, which was compared with the model group, and showed a significant difference(P<0.001). Conclusion: The AA could protect mice from ethanol induced acute liver injury efficiently.
