Abstract:Objective:To study the anti-inflammation effect of volatile oil from Periploca forrestii and the mechanism of action, for providing the basis of the clinical application. Method: The emulsion of volatile oil was prepared. The model of adjuvant arthritis in mice was established with complete freund's adjuvant (CFA) and the changes of nitrogen oxide(NO), malondialdehyde(MDA) content in the serum were determined to estimate the pharmacodynamics of anti-inflammatory activities the in vivo and mouse capillary permeability caused by acetic acid capillary permeability experiment. Rats were randomly divided into control group, model group, positive drug group (tripterygium wilfordii, 6.0 mg·kg-1), the emulsion of volatile oil high dosage group, low dosage group (the dosage 0.375, 0.094 mL·kg-1) by gavage administration.Mouses were randomly divided into control group, positive drug group (dexamethasone, 4 mg·kg-1), the emulsion of volatile oil high dosage group, group,middle dosage group, low dosage group (the dosage 0.500,0.250,0.125 mL·kg-1). According to a set of drug doses to weight 20 mL·kg-1 drug gavage. Result: The results indicate that volatile oil from P. forrestii can obviously inhibit the increase of the mouse's abdominal cavity capillary permeability induced by acetic acid, protect against the paws swelling in adjuvant-induced arthritis mice, decrease NO and MDA in the serums of model mice. The volatile oil can alleviate the pathological responses. Conclusion: The volatile oil from P. forrestii had a marked anti-inflammatory effect.
