Abstract:Objective:To observe the influence of Zexie Danming Drink (ZDD) on serum lipids and adiponectin in hyperlipidemic rats. Method: A high-fat diet was fed 14 d to establish rat model of hyperlipidemia. Rats in different groups were given drugs accordingly for 21 days: ZDD high dose (4.0 g·kg-1), medium dose (2.0 g·kg-1), low dose (1.0 g·kg-1) and Xuezhikang (20 mg·kg-1). Serum triglycerides (TG), cholesterol (TC), high density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), and adiponectin factors (ADP) and liver pathological changes were determined and observed. Result: Compared with model group, TC and TG in ZDD high dose group were significantly lowered (P<0.01), LDL-C decreased significantly (P<0.05), serum ADP level increased significantly l (P<0.01) and with a trend of elevation in HDL-C,. Compared with model group, in the middle dose group serum ADP levelwas significantly increased. Conclusion: ZDD of high dose or medium dose can regulate blood lipids and adiponectin levels, with good improvement for dyslipidemia.
