Abstract:Objective:To observe vascular protection effect of Gegen Qinlian decoction(GQD) in rats with arrhythmia. Method: Sixty rats were randomly divided into six groups: sham group, model group, positive drug group, and three dose groups of GQD (2.16, 4.32, 8.64 g·kg-1).Ligating the left anterior descending artery for 30 min ischemia and then reperfused for 15 min, limb II ECG was investigated in the isxhemia/reperfusion model. After the operation, postoperative radioimmunoassay was used to detect the content of plasma endothelin (ET) and angiotensin II(Ang II). The tumor necrosis factor-α (TNF-α) of serum and the nuclear factor-κB (NF-κB) in myocardial tissue were measured by using ELISA. Result: Compared with the sham operation group, increased AngII,TNF-α and NF-κB expressions were found in model group rats after reperfusion(P<0.01);Compared with the model group, GQD could significantly reduce reperfusion arrhythmia score (P<0.05),NF-κB,TNF-α and ET could be significantly reduced in GQD groups(P<0.01). Conclusion: GQD has a certain protective effect against reperfusion induced arrhythmia, which is related to reducing the content of AngII and then suppressing the expression of NF-κB,TNF-α,ET in infarcted reflow.
