Abstract:Objective:To explore the prevention effect of Xuebijing injection on radiation-induced lung injury in patients with non-small cell lung cancer (NSCLC). Method: Eighty three cases of NSCLC patients underwent radiotherapy and confirmed by pathological examinations were randomly divided into two groups. The treatment group (n=42) received Xuebijing injection from the first day of radiotherapy, the control group (n=41) received radiotherapy alone. The levels of tumor necrosis factor-α (TNF-α), coagulation function, KPS scoring, and incidence of radiation-induced lung injury within 6-month-follow up were observed. Result: The levels of TNF-α in the two groups at the second week and the end of radiotherapy increased obviously, while the increasing degree in the treatment group was obviously smaller than that in the control group. The coagulation function in the two groups had different degree of deterioration, while the deterioration degree in the treatment group was smaller than that in the control group. The KPS scoring in the treatment group at the second week and the end of radiotherapy decreased slightly, and obviously increased 6 months after radiotherapy, and was also higher than that in the control group at the end of radiotherapy and 6 months after the end of radiotherapy. The incidences of early and advanced radiation-induced lung injury in the treatment group were obviously lower than that in the control group. Conclusion: Xuebijing injection has the effect on anti-endotoxin, reducing inflammation factors releasing, adjusting anticoagulation and coagulation function, and increasing the KPS scoring, so as to effectively prevent radiation-induced lung injury and improve the life quality of the patients.
