Abstract:Objective:To Investigate the clinical effect on chronic viral hepatitis B(CHB)treated with integrative Chinese and western medicine. Method: Sixty cases of chronic viral hepatitis B were randomized into observation group (39 cases) and control group (37 cases). The control group was treated with pegasys 180 μg/times,1time/week, subcutaneously; the observation group was treated with the Shiwei Xihuangcao granules or Renshen Jianpi wan according to the different traditional Chinese medicine (TCM) symptoms on the basis of the control group. The course of treatment was 48 weeks. Liver function, TCM syndrome score, HBV-DNA quantitative and HBV markers of two groups were observed. Result: The level of aspartate aminotransferase (AST), alanine transaminase (ALT), total bilirubin (TBil) of the observation group was lower than that of the control group after 24, 48 weeks treatment (P<0.05, P<0.01). The TCM syndrome score of the observation group was lower than the control group after 12, 24, 48 weeks treatment(P<0.01). The level of serum HBV-DNA of the observation group was lower than the control group after 24, 48 weeks treatment (P<0.05,P<0.01). The Liver function normalization rate and HBV-DNA negative rate of the observation group were better than the control group after 48 weeks treatment(P<0.05). Conclusion: Integrative treatment of CHB has more obvious clinical advantages than the simple treatment of western medicine and worth to promote to use clinically.
