Abstract:Objective:To observe the effect of herbs of reinforcing the kidney and promoting blood flow combined with low dose of memantine for treatment of cognitive dysfunction after stroke. Method: From January 2009 to June 2011, 80 patients with after stroke cognitive dysfunction were collected as investigative cases. And all patients were given the treatment of herbs of reinforcing the kidney and promoting blood flow combined with small dose of memantine. Then we evaluated the curative effect by applying the simple intelligent state examination scale (MMSE) and Montreal cognitive assessment scale (MoCA, Beijing edition) before treatment, a month and three months after treatment. Result: The MMSE score of all patients was 24.84±3.21 and MoCA score was 23.76±3.00 before treatment, those were all below the normal reference value of 26.Along with the treatment continuance, MMSE and MoCA scores were increased gradually, they were 27.28±4.57 and 26.47±3.43 at one month after treatment, and 29.78±4.44 and 28.89±3.37 at three months after treatment. They were higher than those of before treatment (P<0.05). Along with treatment continuance, significant efficiency gradually raised. The significant efficiency at three months after treatment was 21.25%, which was higher than that at a month after treatment (15.0%) (P<0.05); The total effective rate at three months after treatment was 86.25%, and those at a month after treatment was 83.75%, without significant difference. Conclusion: Treatment by herbs of reinforcing the kidney and promoting blood flow combined with small dose of memantine could improve cognitive function for cognitive dysfunction after stroke. The effect is clear and worthwhile to be applied clinically.
