Abstract:Objective:Explore combining traditional Chinese and western medicine treatment of prophase diabetic nephropathy therapy effect. Method: Selection in January 2010 to december 2011 in our hospital of 72 cases with prophase diabetic nephropathy, the western medicine that oral enalapril(25 mg,bid) and pancreatic enzyme(240 U,tid)symptomatic treatment of peptides 37 cases as control group, in western medicine treatment on the basis of traditional Chinese medicine to serve with the 34 patients in as a research group. The two groups have been treatmented for 12 weeks. Observe and compare the curative effect of two groups, the determination of the urea nitrogen (BUN) before and after, creatinine (SCr), 24 h urine protein quantitative change. Result: The total effective rate of 82.8% in the control group, the total effective rate of 94.8% in the treatment group treatment of compared with the two groups,the statistically is significant difference (P<0.05); The two groups after treating BUN, SCr, 24 h urine protein quantitative obviously lower than that, there is statistically significant (P<0.05), compared with controls group , the effectiveness of the treatment group's each index is much better than control group, the difference was statistically significant (P<0.05). Conclusion: Combining traditional Chinese and western medicine treatment of diabetic nephropathy therapy effect significantly, which is worthy be popularized.