Abstract:Objective: To optimize extraction conditions of Runfu Zhiyang liposome gels. Method: With the content of hydroxy safflower yellow A and matrine,extract yield as comprehensive evaluation index,based on single factor test,effects of soaking time,extraction time and the amount of water on technology was investigated by orthogonal test. Result: Optimum extraction technology was as following:extracted 2,1.5 h with 12,10 times the amount of water after soaking 0.5 h,respectively. Conclusion: This optimized technology was stable and feasible,it offered expermental basis for further development of Runfu Zhiyang liposome gels.