Abstract:Objective: To investigate the influence on the adhesive activity and effective component content in American ginseng cataplasm with different radiation doses. Method: A HPLC method was established for the determination of 3 kinds of ginsenoside in American ginseng cataplasm; changes of adhesive activity and main constituents were compared in samples irradiated with different radiation doses. Result: 60Co-γ radiation with different radiation didn't lead the adhesive activity of American ginseng Cataplasm to change obviously, and the content of ginsenoside Rg1, ginsenoside Re and ginsenoside Rb1 in American ginseng cataplasm was about 8, 90,90,22 and 189 μg·cm-2 respectively before and after 60Co-γ radiation. Conclusion: There is no obvious influence on the adhesive activity and the content of main constituents of American ginseng cataplasm before and after sterilization with the method of 60Co-γ radiation.