Abstract:Objective: To study the effect of different drying methods on butylphthalide in different parts of Ligusticum chuanxiong. Method: The content of butylphthalide in L. chuanxiong from different drying methods and different parts was determined by HPLC. Result: There was a good linear relationship between butylphthalide and peak area when the sample injection was from 0.515 2-5.152 0 μg (r=0.999 9), the quantification limit was 5.515 2 mg·L-1, the average recovery was 100.1%, and RSD was 1.10% (n=9). The butylphthalide content in different parts of L. chuanxiong arranged in descending order was rhizome>stem>leaf. Different drying methods had some influence on the butylphthalide content in different parts of L. chuanxiong. Conclusion: Butylphthalide content in different parts of L. chuanxiong is different. Among the three drying methods, oven-drying after sunshine is the optimal one for L. chuanxiong.