Determination content of Magnolol in Huoxiang Zhengqi Capsules Separate from Different Pharmaceutical Factories by Near-infrared Spectroscopy

Abstract:

Objective: To determine the content of Magnolol in Huoxiang Zhengqi capsules by near-infrared spectroscopy(NIR). Method: Determined the content of magnolol in 109 samples by HPLC. Collected their NIR spectrograms data,calibration model of magnolol was established by the Partial least squares regression analysis. Result: The correlation coefficients (R²), the root-mean-square error of cross-validation and the root-mean-square error of calibration (RMSEC) of the calibration model for magnolol were 0.945 6,0.054 3,0.024 5; and the root-mean-square error of prediction (RMSEP) was 0.045 9, the average rate of recovery was 101.26%. Conclusion: The method is steady, accurate, and can be applied for the fast determination of magnolol within. Huoxiang Zhengqi capsules.