Effect of Xiaoyong Kuidekang on Expressions of GAS and MTL in Rat Ulcer Model

Abstract:

Objective: To study the effect of Xiaoyong Kuidekang on expressions of gastrin (GAS) and motilin (MTL) in rat ulcer model and to explore the mechanism of gastric ulcer treated by Xiaoyong Kuidekang. Method: The rats were randomly divided into 5 groups randomly: normal group,sham group,ulcer model group,Xiaoyong Kuidekang group and Omeprazole group.Acetic acid was applied to a certain part of the gastric mucosa to establish the ulcer model. The Xiaoyong Kuidekang and Omeprazole treatment group had been implemented with drugs since the 2nd day after the operation, the serum was collected on the 11 th day and the content of GAS and MTL were measured by ELISA method. Result: The GAS and MTL content of serum in ulcer model group was higher than that in the control group and the sham group (P<0.01), the GAS and MTL content of serum was lower in the Xiaoyong Kuidekang group and Omeprazole group than those in the ulcer model group (P<0.01). Conclusion: The Xiaoyong Kuidekang may be mediated by decreased the GAS and MTL content of serum,so as to achieve the protection of gastric mucosa and promote ulcer healing effect.