Protect Effect of Simiao Yong'an Decoction on Thromboangitis Obliterans in Rats

Abstract:

Objective: To observe the effect of Simiao Yong'an decoction(SMYA) on blood lipid and hemorheology in thromboangitis obliterans(TAO) rats. Method: Rats were randomly divided into 6 groups:control group, model group, mailuoning group(2.7 g·kg^-1), low, medium and high dose groups of SMYA(24.3,16.2,8.1 g·kg^-1). The drugs were administrated to rats for 15 days. The rat TAO model was made by injecting sodium laurate into the femoral artery of rats, and the level of serum lipid and blood rheology were tested. Result: SMYA could obviously lower triglycerides(TG), total cholesterol(TC), oxidized-low density lipoprotein(OX-LDL), blood viscosity and erythrocyte sedimentation rate values, and increase high density lipoprotein (HDL). Conclusion: SMYA can adjust fatty substance metabolism and lower blood lipid and improve hemorrheology of TAO rats,and has therapentic effect on TAO.