Effect of Mongolian Medicine GEI Wang-9 with Cool Nature and Removing Heat on Acute Liver Failure Induced by Carbon Tetrachloride

Abstract:

Objective: To observe the effect of Mongolian medicine GEI Wang-9 on acute liver failure induced by carbon tetrachloride CCl₄. Method: methods 30% carbon tetrachloride was used to induce model of acute liver failure. After 24 h,indexes alanine aminotransferase(ALT),aspartate aminotransferase(AST),nitric oxide(NO),active of nitric oxide composite enzyme (NOS) of serum and liver index and pepsin in the stomach homogenate were detected in normal group,model group,Mongolian medicine GEI Wang-9 low,middle,high dose groups(1.3,2.6,3.9 g·kg^-1), respectively. Result: In the model group, compared with normal group, serum AST, ALT extremely increased significantly (all P<0.01); NO,nitric oxide composite enzyme and liver indexall increased significantly (P<0.05). Compared with model group, GEI Wang-9 low doses decreased significantly the serum NO,nitric oxide composite enzymeall (P<0.05). GEI Wang-9, middle doses decreased significantly the serum AST,ALT(P<0.01, P<0.05, respectively); and NO,nitric oxide composite enzyme and liver index reduced significantly (P<0.05). High doses reduced significantly the serum AST,ALT(P<0.01, P<0.05,respectively); NO,nitric oxide composite enzyme and liver index reduced significantly (P<0.05). Conclusion: Mongolian medicine GEI Wang-9 has protective actions on acute liver failure induced by carbon tetrachloride.