Effects of Xiaochaihu Decoction on VIP,Gastric Emptying and Small Intestine Advance Rate in Functional Dyspepsia Rats

Abstract:

Objective: To observe the effects of Xiaochaihu decoction on vasoactive intestinal peptide(VIP),gastric emptying and small intestine advance rate in functional dyspepsia (FD) rats. Method: 48 rats were randomly divided into four groups: blank group, model group, Xiaochaihu decoction group and domperidone group, each group had 12 rats. FD models were established by chronic restraint stress and excessive fatigue and irregular feeding, once per day for continuous 3 weeks. Then feed the rats in different groups with normal saline, normal saline, Xiaochaihu decoction and Domperidone liquor respectively by intragastric administration for continuous 14 days. After 14 days intragastric administration, VIP of each rat was detected. Gastric emptying and small intestine advance rate of each rat were tested. Result: Compared to the blank group, gastrointestinal Hormone VIP and gastric residue obviously increased while small intestine advance rate significantly decreased in model group (P<0.05 or P<0.01). Compared to the model group, gastrointestinal hormone VIP and gastric residue obviously decreased while small intestine advance rate significantly increased in the Xiaochaihu decoction and domperidone group (P<0.05 or P<0.01). Conclusion: Xiaochaihu decoction can reduce gastrointestinal hormone VIP, advance gastric emptying and small intestine advance rate in functional dyspepsia rats.