Iintervention Effect of Activating Blood Circulation and Eliminating Stasis Chinese Herbals on Vessel Remolding of COPD

Abstract:

Objective: Observe the pulmonary vascular pathological change in chronic obstructive pulmonary disease(COPD) rat models of application for activating blood circulation and eliminating stasis drugs, explore the vascular remodeling of COPD. Method: Make COPD models by droping lipopolysaccharide (LPS) into tracheal and passive smoking method. From 29^th to 42^th days, group H are gave intraperitoneal injection of Chuanqing solution 8 mL·kg^-1·day^-1; group C are gave volumetric saline. Execute the three groups rats in sixth weeks, observe the pathological changes of pulmonary vessels in rat models applied activating blood circulation and eliminating stasis drugs. Result: Compared to group N there are characteristically changes in group C and H,but different in degree. Compared to group N and C, vascular smooth muscle cells of group H have mild hyperplasia, the wall was thickened slightly, the ratio of blood vessel wall/blood vessel wall and hemal wall area/vascular area are significantly (P<0.01).Under the electron microscopy observation, the endothelial cells, the basement membrane, mitochondria and shelf small body of group N are normal; group C appear obvious changes. The pinocytotic vesicles of endothelial cells increased,mitochondrion edema or vacuoles degenerate. The nuclei have become obvious tendency of becoming pyknotic. Many nucleation white blood cells are blocked in the capillary lumen; endothelial cells, the basement membrane, mitochondria and lamellar body in group H are basically normal. There are a few nucleation white blood cells in the capillary lumens. Conclusion: Traditional Chinese medicine for activating blood circulation and eliminating stasis can slow or improve the blood vessels remodeling of COPD. It guides the treat should accord to its different stages in the process of development and combined with illness, use the drugs for activating blood circulation and eliminating stasis flexibly, give a scientific understanding of the importance in control of COPD to improve the clinical effect.