Analgesic and Anti-inflammatory Effect of the Alkaloid in Chelidonium majus Extract

Abstract:

Objective: To study the anti-inflammatory, analgesic effects of Chelidonium majus extract. Method: Writhing method, hot-plate method and formalin pain model were used to evaluate the analgesic effect. The inhibition of auricle edema induced by xylene and mouse peritoneal capillary permeability experiment were used to assess the anti-inflammatory effect. Naloxone test was used to interpret the analgesic mechanisms of the extract. Result: High dose group of C. majus extract significantly decreased the twisting times in mice induced by acetic acid(P<0.05),and obviously inhibited the swelling of mouse pinna induced by xylene(P<0.01). Conclusion: C. majus extract has significant analgesic and anti-inflammatory effects. Its analgesic effects are mainly peripheral and not antagonized by Naloxone.