Effect of Salvia Miltiorrhiza and Ligustrazine Injection in Combination with Traditional Chinese Medicine Enema on Chronic Kidney Disease and its Mechanism

Abstract:

Objective: To observe the effect of salvia miltiorrhiza and ligustrazine injection in combination with traditional Chinese medicine enema on chronic kidney disease (CKD), endothelin (ET), 6-keto-prostaglandin F_1α (6-keto-PGF_1α) and thromboxane B₂ (TXB₂). Method: Seventy patients with stage 3-4 CKD were randomly divided into observation group and control group (n=35 each). Control group was received western medicine therapy and rhubarb fluid enema. 200 mL rhubarb fluid were given via retention enema for 1-2 h and inserted into the intestine 20cm daily. The patients in observation group, on the basis of control group, were received salvia miltiorrhiza and ligustrazine injection 15 mL, diluted with 100 mL saline, iv, for 10 days. After two days' rest, the patients were received another course. There were two courses. Serum creatine (SCr), blood urea nitrogen (BUN), ET, 6-Keto-PGF_1α and TXB₂ were tested before and after treatment. Result: The total effective rate of observation group (71.43%) was higher than control group (45.71%) with a significant difference (P<0.05). BUN and SCr in observation group were lower than control group (P<0.05,P<0.01); After treatment, ET and TXB₂ were decreased, and 6-keto-PGF_1α increased in two growps. ET and TXB₂ in observation group were lower than those in control group, however, 6-keto-PGF_1α in observation group was higher than that in control group (P<0.05). Conclusion: Salvia miltiorrhiza and ligustrazine injection can decrease BUN and SCr in patients with stage 3-4 CKD, improve clinical efficacy, ameliorate hypercoagulative state and protect vascular endothelial function.