Effect of Shenkang Injection as an Adjunctive Treatment on Early Diabetic Nephropathy and on Patient's Oxidative Stress

Abstract:

Objective: To observe the effect of Shenkang injection as an adjunctive treatment on early diabetic nephropathy (DN) and on patients' oxidative stress. Method: Sixty-six DN patients were randomly divided into observation group and control group (n=33 each). The patients in control group were received tight control of diet, blood glucose and blood pressure to maintain normal levels. They were orally taken enalaprilat, 5 mg daily. The patients in observation group, on the basis of control group, received Shenkang injection 100 mL mixed with 300 mL 5%glucose, iv,gtt, 1 time daily. The treatment course of the two groups lasted 4 weeks. Urinary albumin excretion rates (UAER), β₂-microglobulin (β₂-MG), albumin to creatinine ratio (ACR), oxidative stress indexes malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity in the two groups were observed. Result: After treatment, UAER, β₂-MG and ACR in observation group were lower than those in control group (P<0.01); SOD and T-AOC in observation group were significantly increased and higher than those in control group (P<0.01). MDA in observation group was significantly decreased and lower than that in control group (P<0.01). The total effective rate of observation group (84.84%) was higher than that in control group (63.64%) with a significant difference (P<0.01). Conclusion: Shenkang injection can decrease UAER, β₂-MG and ACR in patients with early diabetic nephropathy and improve clinical efficacy, the mechanism of which may be associated with reducing oxidative stress and enhancing anti oxidative stress ability.