Effect of Shenkang Injection as an Adjunctive Treatment on Early Diabetic Nephropathy and on Patient's Oxidative Stress

Abstract:

Objective: To observe the effect of Shenkang injection as an adjunctive treatment on early diabetic nephropathy (DN) and on patients' oxidative stress. Method: Sixty-six DN patients were randomly divided into observation group and control group (n=33 each). The patients in control group were received tight control of diet, blood glucose and blood pressure to maintain normal levels. They were orally taken enalaprilat, 5 mg daily. The patients in observation group, on the basis of control group, received Shenkang injection 100 mL mixed with 300 mL 5%glucose, iv,gtt, 1 time daily. The treatment course of the two groups lasted 4 weeks. Urinary albumin excretion rates (UAER), β₂-microglobulin (β₂-MG), albumin to creatinine ratio (ACR), oxidative stress indexes malondialdehyde (MDA), superoxide dismutase (SOD) and total antioxidant capacity in the two groups were observed. Result: After treatment, UAER, β₂-MG and ACR in observation group were lower than those in control group (P<0.01); SOD and T-AOC in observation group were significantly increased and higher than those in control group (P<0.01). MDA in observation group was significantly decreased and lower than that in control group (P<0.01). The total effective rate of observation group (84.84%) was higher than that in control group (63.64%) with a significant difference (P<0.01). Conclusion: Shenkang injection can decrease UAER, β₂-MG and ACR in patients with early diabetic nephropathy and improve clinical efficacy, the mechanism of which may be associated with reducing oxidative stress and enhancing anti oxidative stress ability.

Key words:diabetic nephropathy;Shenkang injection;oxidative stress