Analysis on Clinical Trials of Chinese Medicinal Injection Used in Stroke Concerning Rational and Safe Medication

Abstract:

Objective: To evaluate proper and safe medication in acute phase of ischemic stroke treated with Chinese medicinal injection. Method: Clinical studies involving acute stage of ischemic stroke treated with Chinese medicinal injection published in Chinese from 2012 January to November were electronically searched from CBM, CNKI, and CMJD and assessed by the inclusive and exclusive criteria. The data were extracted, grouped by the category, administration, dialectic medication, combination and safety evolution and then analyzed. Result: Eighty-three papers were included finally. 18 kinds of Chinese medicinal injection were used altogether. All were administrated by intravenous injection once per day, while the daily dose, first use time, and treatment course were different. None of injections was applied by the principle of symptom differentiation. The combination treatment included platelet aggregation inhibitors, anticoagulants, anti-fibrinogen, neuroprotectors, dehydrant, thrombolysis, rehabilitation and high pressure oxygen, except Chinese medicinal injection and decoction of Chinese herbs. Fifty-five studies conducted safety assessment and 40 of them found no adverse reaction. Conclusion: The unrational application of Chinese medical injections existsin in Chinical research. The principle of symptom differentiation and strict conduction with therapeutic indication are suggested in research and clinical application of Chinese medicinal injection. More attention should be paid to safety monitoring and side effect reporting.