Abstract:Objective: To investigate the changes of vascular endothelial function in early diabetic retinopathy patients and the effect of compound Danshen droppills on intervention. Method: Fixty-five patients with early diabetic retinopathy were selected and divided into two groups(routine group and Danshen droppills group).routine group was treated with insulin; the Danshen droppills group was was treated with Compound Danshen droppills (10# Tid)combined with insulin. 31 healthy as control group. After 8 weeks treatment, the endothelium-dependent flow-mediated dilatation(FMD) of brachial artery was determined with ultrasound, and the levels of fasting blood glucose(FBG), glycosylated hemoglobin(HbA1c),cholesterol (TC), triglyceride (TG), high sensitivity C-reactive protein (hs-CRP), intercellular adhesion molecule-1(ICAM-1)and endothelin-1(ET-1) in three groups were measured respectively before and after treatment. The change of fluorescein angiography in early diabetic retinopathy patients were observed before and after treatment. Result: All patients with early diabetic retinopathy showed that the FBG, HbA1c,TC,TG,hs-CRP, ICAM-1 and ET-1 was higher than that of the controlled group(P<0.05), the FMD was lower than the controlled group(P<0.05). After treatment fundus fluorescence angiography in Danshen droppills group was obviously improved than befor therapy,the hs-CRP, ICAM-1,ET-1 in the Danshen droppills group[(8.76±1.26)mg·L-1, (407.82±87.45) μg·L-1,(96.68±10.69) ng·L-1] was decreased more significantly than routine group[(18.78±2.42)mg·L-1,(597.79±60.74) ng·L-1,(184.5±10.78) ng·L-1] (P<0.05).After treatment the FMD in the Danshen droppills group was increased more significantly than routine group [(11.88±3.57)% vs (9.17±0.54)%](P<0.05). Conclusion: The compound Danshen droppills can effectively reduce the body's inflammationrecovery and recovery vascular endothelial function in patients with early diabetic retinopathy.
