Optimization of Preparation Technology of Total Glucosides of Buyang Huangwu Decoction Capsules

Abstract:

Objective: To optimize preparation process of total glucosides of Buyang Huanwu decoction(BYHWT) capsules. Method: With the content of astragaloside Ⅳ and extract yield as indexes,water extraction process of this capsules was optimized by orthogonal design.Isolation and purification of total glucosides from BYHWT was achieved by using 732 cation exchange resin firstly,then extracting with chloroform,and finally using DA-201 macroporous resin.Molding technology of this capsules was investigated by single factor tests. Result: Optimum water extraction technology was:extracted 2 times with 10,8 times the volume of water,1 h per time.Lactose as hygroscopic agent,80% ethanol as wetting agent,relative humidity should be less than 50% for production environment,1.02 g particles should be dispensed into 6 No. 2 capsules. Conclusion: Optimized extraction and molding technology was reasonable and feasible,which provided a reference for industrial production of total glucosides of BYHWT capsules.