Abstract:Objective: To investigate effects of different grinding degree of medicinal materials and soaking time on ginsenoside Rg1 content and total solid content in Shiyifang vinum. Method: With ginsenoside Rg1 as index,which was determined by HPLC,ginsenoside Rg1 content and total solid content changes in Shiyifang vinum were investigated after soaked different time(4,6,8 months) and crushed into coarse particles(5-10 mm),the most coarse powder(2 mm),coarse powder(0.85 mm). Result: After medicinal materials were crushed into coarse particles,the content of ginsenoside Rg1 was the highest in Shiyifang vinum.Total solid content was similar between crushed into coarse particles,immersed 6 months and crushed into coarse particles,immersed 8 months,there was no significant difference. Conclusion: Quality of Shiyifang vinum was good by crushing medicinal materials into coarse particles and soaking 6 months.