Effects of Gualou Xiebai Decoction on Myocardial Ischemia-reperfusion Injury

Abstract:

Objective: To investigate the curative effect of Gualou Xiebai decoction on physiology, serology, histology target of myocardial ischemia-reperfusion injury. Method: The ischemic model was made by occluding the left anterior descending artery (LAD) in rats. Not only the change of ST segment was observed, but also the activity of creatine kinase-MB (CK-MB),lactate dehydrogenase (LDH) and superoxide dismutase (SOD) and maleic dialdehyde (MDA) in serum were measured. The histological changes were observed. Result: Compared with the model group, the T amplitude of wave was lowered apparently during the period of 10 to 30 min in Gualou Xiebai decoction group. Compared with the model group, MAD level in Gualou Xiebai decoction was reduced(P<0.05), and the level of SOD was increased(P<0.05). Histopathological results showed that the high dose group was superior to the low dose group. Conclusion: Gualou Xiebai decoction has a protective effect on myocardial ischemia-reperfusion injury.