Effect of Tianshu Capsule on Migarine Model Induced by Reserpine

Abstract:

Objective: To study the effect and mechanism of Tianshu capsule on the migraine's mice, which was composed of Gastrodiae Rhizoma and Ligustici Chuanxiong Rhizoma. Method: Model was building on ICR mice after subcutaneous injection of reserpine 0.1 mg·kg^-1·d^-1×12 d, control group mice were injected 0.9% sodium chloride injection, treatment were started on the seventh day of modeling for 6 consecutive days, dose were 1.55, 4.65 g·kg^-1. The pain threshold was tested on the twelve day, the clotting time was tested next day and concentration of serotonin (5-HT), noradrenaline(NA) in the brain.was detected. Zolmitriptan tablets were used as a positive durg. Result: Compared with model group, the tianshu capsule could increase the pain threshold(P<0.01), prolong the clotting time(P<0.01), increase the concentration of 5-HT and NA in brain(P<0.05,P<0.01). Compared with positive drug, the capsule could increase the concentration of 5-HT(P<0.05). Conclusion: The capsule can treat the migraine's mice by balancing release of 5-HT, inhibiting vascular dilatation of migraine attacks.